| Remote Magnetically Oriented Xanthan-Biochar Microtube-Fe3O4-Molecularly Imprinted Biopolymer Hydrogel toward Electrochemical Enantioselection of L-Tryptophan |
| کد مقاله : 1114-17THECSI |
| نویسندگان |
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فاطمه حسینی1، خیبر دشتیان1، روح اله زارع دورابی *2 1دانشگاه علم و صنعت ایران 2گروه شیمی تجزیه، دانشکده شیمی، دانشگاه علم و صنعت ایران |
| چکیده مقاله |
| L-Tryptophan is known as a vital biological amino acid associated with metabolism and protein synthesis precursor and deficiency and its abundance leads to a decrease in neurotransmitters and neurological diseases [1]. Currently, developing portable electrochemical sensors for monitoring and enantioselection of tryptophan is a hot topic, and there are significant challenges [2]. Hydrogels with polymeric networks can be applied as a medium to realize solid-state sensing. However, it is still a hard task to enable hydrogel to simultaneously possess effective mass transfer, mechanical robustness as well as easy and tight adhesion to sensing electrodes. Routinely, a hydrogel with improved adhesion to the electrode surface by introducing additives may deteriorate the mass transfer capability [3]. Increasing the porosity of hydrogel could enhance mass diffusion but sacrifices mechanical robustness. Herein, we developed a remote magnetically oriented xanthan-biochar microtube (derived from Loofah)-Fe3O4-molecularly imprinted polydopamine hydrogel and applied it as an electrochemical enantioselective sensor for the L-tryptophan recognition. The physicochemical and electrochemical characterization results confirm the successful synthesis of as-proposed materials. The operational factors such as pH, response time, loading sample volume and loading active materials mass were optimized and at optimization condition, the affordable linear range (0.005-500µM) and desirable limit of detection (1.5nM) were founded. Additionally, the proposed electrochemical sensor showed good reproducibility, and desirable selectivity towards the determination of L-Try, which makes it suitable for the analysis of L-Try in human plasma and serum samples. It paves an attractive, accessible, and effective strategy to on-site evaluate L-Trp level for forewarning healthcare monitoring. |
| کلیدواژه ها |
| L-Tryptophan, Electrochemical Sensor, Hydrogels, Xanthan-Biochar Microtube, Molecularly Imprinted Biopolymer |
| وضعیت: چکیده برای ارائه به صورت پوستر پذیرفته شده است |